Blar i forfatter "Stenmark, Harald Alfred"

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    • ATPase activity of DFCP1 controls selective autophagy 

      Nahse-Kumpf, Viola; Raiborg, Camilla; Tan, Kia Wee; Mørk, Sissel; Torgersen, Maria Lyngaas; Wenzel, Eva; Nager Grifo, Mireia; Salo, Veijo T.; Johansen, Terje; Ikonen, Elina; Schink, Kay Oliver; Stenmark, Harald Alfred (Journal article; Tidsskriftartikkel, 2023-07-08)
      Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ...

    • Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy 

      Mejlvang, Jakob; Olsvik, Hallvard Lauritz; Svenning, Steingrim; Bruun, Jack-Ansgar; Abudu, Yakubu Princely; Larsen, Kenneth Bowitz; Brech, Andreas; Hansen, Tom Egil; Brenne, Hanne Britt; Hansen, Terkel; Stenmark, Harald Alfred; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-17)
      It is not clear to what extent starvation-induced autophagy affects the proteome on a global scale and whether it is selective. In this study, we report based on quantitative proteomics that cells during the first 4 h of acute starvation elicit lysosomal degradation of up to 2–3% of the proteome. The most significant changes are caused by an immediate autophagic response elicited by shortage of amino ...